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René Wintjens Selected Research

Ethionamide (Trecator-SC)

3/2024Crystal structure of the Mycobacterium tuberculosis VirS regulator reveals its interaction with the lead compound SMARt751.
1/2022The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis.
1/2020Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity.
1/2019A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR.
3/2017Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.
4/2012Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands.

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René Wintjens Research Topics

Disease

8Tuberculosis (Tuberculoses)
03/2024 - 05/2009
4Infections
12/2022 - 11/2010
3Wounds and Injuries (Trauma)
06/2020 - 03/2004
1Hypocalcemia
01/2022
1Hyperphosphatemia
01/2022
1Bronchitis
06/2020
1Malaria
06/2020
1Meningitis
06/2020
1Abdominal Pain (Pain, Abdominal)
06/2020
1Hypercholesterolemia
03/2016
1Hyperlipoproteinemia Type II (Familial Hypercholesterolemia)
03/2016
1Glioblastoma (Glioblastoma Multiforme)
01/2016
1Melanoma (Melanoma, Malignant)
01/2016
1Neoplasms (Cancer)
01/2016
1Glioma (Gliomas)
01/2016
1Stomatocytosis I
01/2013
1Paralysis (Palsy)
01/2013
1Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis)
10/2012
1Meningococcal Infections
05/2012
1Obesity
10/2011
1Alzheimer Disease (Alzheimer's Disease)
12/2002

Drug/Important Bio-Agent (IBA)

6Ethionamide (Trecator-SC)FDA Link
03/2024 - 04/2012
3ProdrugsIBA
03/2024 - 09/2015
3Proteins (Proteins, Gene)FDA Link
01/2019 - 03/2004
3LatexIBA
01/2016 - 03/2004
2LigandsIBA
03/2024 - 04/2012
2Anti-Bacterial Agents (Antibiotics)IBA
01/2022 - 05/2012
1Lysine (L-Lysine)FDA Link
12/2022
1Histones (Histone)IBA
12/2022
1MethyltransferasesIBA
12/2022
1Vitamin DFDA LinkGeneric
01/2022
1Mixed Function Oxygenases (Monooxygenases)IBA
01/2022
1Parathyroid Hormone (Parathormone)IBA
01/2022
1Cathartics (Purgatives)IBA
06/2020
1OxadiazolesIBA
01/2020
1SMARt-420IBA
03/2017
1Apolipoproteins E (ApoE)IBA
03/2016
1tyrosyl- seryl(O- t- butyl)- glycyl- phenylalanyl- leucyl- threonine(O- t- butyl) (BUBU)IBA
01/2016
1pretomanidIBA
09/2015
1telacebecIBA
09/2013
1Ammonium CompoundsIBA
01/2013
1pyrazinamide deamidaseIBA
10/2012
1Penicillin G (Benzylpenicillin)FDA LinkGeneric
05/2012
1Penicillins (Penicillin)FDA Link
05/2012
1DNA (Deoxyribonucleic Acid)IBA
04/2012
1Sweetening Agents (Sweeteners)IBA
10/2011
1Plant ProteinsIBA
10/2011
1EnzymesIBA
11/2010
1PolymersIBA
11/2010
1Thymine NucleotidesIBA
05/2009
1tau Proteins (tau Protein)IBA
12/2002
1NIMA-Interacting Peptidylprolyl IsomeraseIBA
12/2002

Therapy/Procedure

1Traditional Medicine (Folk Remedies)
06/2020
1Therapeutics
09/2013